Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.S465T

c.1393T>A

Surrounding Variants

2 papers

NM_004333.6

p.S465A

c.1393T>G

1 paper

NM_004333.6

p.S465fs

c.1393_1394fs

1 paper

NM_004333.6

p.D454_G464del11

c.1360_1391del33

8 papers

NM_004333.6

p.S465F

c.1394C>T

1 paper

NM_004333.6

p.S465C

c.1394C>G

2 papers

NM_004333.6

p.S465Y

c.1394C>A

249 papers

NM_004333.6

p.G464V

c.1391G>T

21 papers

NM_004333.6

p.G464A

c.1391G>C

150 papers

NM_004333.6

p.G464E

c.1391G>A

1 paper

NM_004333.6

p.G464delins

c.1390_1391delinsAT

5 papers

NM_004333.6

p.G466*

c.1396G>T

1 paper

NM_004333.6

p.G464*

c.1390G>T