Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

1–12 of 220 variants

28 papers

NM_001135651.3

p.K296R

c.887A>G

11 papers

NM_001135651.3

p.G130R

c.388G>A

11 papers

NM_001135651.3

p.G130R

c.388G>C

11 papers

NM_001135651.3

p.G130R

c.388G>A

6 papers

NM_001135651.3

p.M11L

c.31A>C

6 papers

NM_001135651.3

p.K64E

c.190A>G

6 papers

NM_001135651.3

p.A109S

c.325G>T

5 papers

NM_001135651.3

p.M11L

c.31A>T

5 papers

NM_001135651.3

p.S97F

c.290C>T

5 papers

NM_001135651.3

p.Q236*

c.706C>T

4 papers

NM_001135651.3

p.T446A

c.1336A>G

4 papers

NM_001135651.3

p.T451A

c.1351A>G