Varaico: Literature-Extracted Genetic Variants

LYN

213 papers

RefSeq Summary

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding differ...

Pfam Domains

SH3_1aa 69–115UCSCSH3 domain

SH2aa 129–211UCSCSH2 domain

PK_Tyr_Ser-Thraa 247–497UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LYN proto-oncogene, Src family tyrosine kinase

HGNC Alias Symbol

JTK8

Papers

RefSeq ID

Protein change

DNA change

1–12 of 197 variants

8 papers

NM_002350.4

p.Y508F

c.1523A>T

6 papers

NM_002350.4

p.L105L

c.315T>A

4 papers

NM_002350.4

p.D385Y

c.1153G>T

4 papers

NM_002350.4

p.Y508H

c.1522T>C

4 papers

NM_002350.4

p.Y508*

c.1524C>A

4 papers

NM_002350.4

p.Y508*

c.1524C>G

3 papers

NM_002350.4

p.D189Y

c.565G>T

3 papers

NM_002350.4

p.I227V

c.679A>G

3 papers

NM_002350.4

p.E435K

c.1303G>A

2 papers

NM_002350.4

p.E28K

c.82G>A

2 papers

NM_002350.4

p.A139T

c.415G>A

2 papers

NM_002350.4

p.L154F

c.460C>T