Varaico: Literature-Extracted Genetic Variants

Gene:MCL1
Variant:p.S162W

MCL1

397 papers

RefSeq Summary

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell sur...

Pfam Domains

Bcl-2aa 60–159UCSCApoptosis regulator proteins, Bcl-2 family

Gene Aliases

HGNC Name

MCL1 apoptosis regulator, BCL2 family member

HGNC Alias Symbols

BCL2L3; Mcl-1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_021960.5
p.S162W
c.485C>G
Surrounding Variants
1 paper
NM_021960.5
p.S162L
c.485C>T
2 papers
NM_021960.5
p.S162A
c.484T>G
1 paper
NM_021960.5
p.S162S
c.486G>T
1 paper
NM_021960.5
p.S162S
c.486G>C
10 papers
NM_021960.5
p.T163A
c.487A>G
1 paper
NM_021960.5
p.P161L
c.482C>T
1 paper
NM_021960.5
p.P161delins
c.481_482delinsTT
1 paper
NM_021960.5
p.P161S
c.481C>T
2 papers
NM_021960.5
p.P164T
c.490C>A
1 paper
NM_021960.5
p.L160I
c.478C>A
2 papers
NM_021960.5
p.P165S
c.493C>T
2 papers
NM_021960.5
p.S159L
c.476C>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."