Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.D1002_D1010delins

c.3005_3028delinsCAGAAA

Surrounding Variants

2 papers

NM_000245.4

p.D1002A

c.3005A>C

1 paper

NM_000245.4

p.D1002V

c.3005A>T

2 papers

NM_001127500.3

p.D1020N

c.3058G>A

NM_000245.4

p.D1002N

c.3004G>A

1 paper

NM_000245.4

p.D1002_Y1003del1

c.3005_3007delACT

1 paper

NM_000245.4

p.D1002delFs

c.3004delG

1 paper

NM_000245.4

p.V1001_P1008delins

c.3003_3023delinsTACAAGCCTATCCAAATG

13 papers

NM_000245.4

p.Y1003N

c.3007T>A

5 papers

NM_000245.4

p.Y1003H

c.3007T>C

NM_001127500.3

p.Y1021H

c.3061T>C

1 paper

NM_000245.4

p.Y1003fs

c.3007_3008fs

9 papers

NM_000245.4

p.Y1003S

c.3008A>C

12 papers

NM_000245.4

p.Y1003C

c.3008A>G

NM_001127500.3

p.Y1021C

c.3062A>G

40 papers

NM_000245.4

p.Y1003F

c.3008A>T

NM_001127500.3

p.Y1021F

c.3062A>T