Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

110 papers

NM_000245.4

p.Y1230C

c.3689A>G

NM_001127500.3

p.Y1248C

c.3743A>G

Surrounding Variants

17 papers

NM_000245.4

p.Y1230S

c.3689A>C

2 papers

NM_000245.4

p.Y1230F

c.3689A>T

18 papers

NM_000245.4

p.Y1230*

c.3690T>A

12 papers

NM_000245.4

p.Y1230N

c.3688T>A

96 papers

NM_000245.4

p.Y1230H

c.3688T>C

NM_001127500.3

p.Y1248H

c.3742T>C

18 papers

NM_000245.4

p.Y1230*

c.3690T>G

11 papers

NM_000245.4

p.Y1230D

c.3688T>G

NM_001127500.3

p.Y1248D

c.3742T>G

4 papers

NM_000245.4

p.D1231N

c.3691G>A

1 paper

NM_000245.4

p.M1229I

c.3687G>A

1 paper

NM_000245.4

p.M1229I

c.3687G>C

11 papers

NM_000245.4

p.D1231Y

c.3691G>T

1 paper

NM_000245.4

p.M1229I

c.3687G>T