Varaico: Literature-Extracted Genetic Variants

MGMT

604 papers

RefSeq Summary

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutag...

Pfam Domains

Methyltransf_1Naa 7–83UCSC6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

DNA_binding_1aa 93–174UCSC6-O-methylguanine DNA methyltransferase, DNA binding domain

Gene Aliases

HGNC Name

O-6-methylguanine-DNA methyltransferase

HGNC Alias Name

methylated-DNA--protein-cysteine methyltransferase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

102 papers

NM_002412.5

p.I143V

c.427A>G

Surrounding Variants

1 paper

NM_002412.5

p.L142I

c.424C>A

1 paper

NM_002412.5

p.P144S

c.430C>T

1 paper

NM_002412.5

p.P144Q

c.431C>A

3 papers

NM_002412.5

p.C145S

c.433T>A

3 papers

NM_002412.5

p.C145S

c.434G>C

1 paper

NM_002412.5

p.P140H

c.419C>A

2 papers

NM_002412.5

p.P140R

c.419C>G

6 papers

NM_002412.5

p.P140A

c.418C>G

2 papers

NM_002412.5

p.P140S

c.418C>T

2 papers

NM_002412.5

p.V139V

c.417C>T

3 papers

NM_002412.5

p.V139L

c.415G>C

1 paper

NM_002412.5

p.V139F

c.415G>T