Varaico: Literature-Extracted Genetic Variants

Gene:MPL
Variant:p.Y591insFs

MPL

1,557 papers

RefSeq Summary

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the huma...

Pfam Domains

EpoR_lig-bindaa 25–128UCSCErythropoietin receptor, ligand binding

Gene Aliases

HGNC Name

MPL proto-oncogene, thrombopoietin receptor

HGNC Alias Symbols

CD110; TPOR; THPOR

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_005373.3
p.Y591insFs
c.1772dupA
Surrounding Variants
16 papers
NM_005373.3
p.Y591N
c.1771T>A
3 papers
NM_005373.3
p.Y591H
c.1771T>C
70 papers
NM_005373.3
p.Y591D
c.1771T>G
1 paper
NM_005373.3
p.Y591S
c.1772A>C
4 papers
NM_005373.3
p.Y591F
c.1772A>T
1 paper
NM_005373.3
p.R592_P596delFs
c.1774_1787del14
1 paper
NM_005373.3
p.R592_S597delFs
c.1774_1790del17
2 papers
NM_005373.3
p.Y591*
c.1773C>A
2 papers
NM_005373.3
p.Y591*
c.1773C>G
1 paper
NM_005373.3
p.R592fs
c.1774_1775fs
5 papers
NM_005373.3
p.R592*
c.1774C>T
1 paper
NM_005373.3
p.R592fs
c.1774_1775fs
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."