Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.M858T

c.2573T>C

Surrounding Variants

1 paper

NM_006218.4

p.M858K

c.2573T>A

20 papers

NM_006218.4

p.M858R

c.2573T>G

1 paper

NM_006218.4

p.M858delins

c.2573_2574delinsGA

4 papers

NM_006218.4

p.Q859K

c.2575C>A

3 papers

NM_006218.4

p.Q859H

c.2577A>C

3 papers

NM_006218.4

p.Q859H

c.2577A>T

1 paper

NM_006218.4

p.T856S

c.2567C>G

1 paper

NM_006218.4

p.T856A

c.2566A>G

1 paper

NM_006218.4

p.T856S

c.2566A>T

1 paper

NM_006218.4

p.H855Q

c.2565C>A

1 paper

NM_006218.4

p.Q861fs

c.2581_2582fs

1 paper

NM_006218.4

p.H855Q

c.2565C>G