Varaico: Literature-Extracted Genetic Variants

PREX2

392 papers

RefSeq Summary

The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac fa...

Pfam Domains

RhoGEFaa 27–212UCSCRhoGEF domain

SOS1_NGEF_PHaa 239–359UCSCSOS1/NGEF-like PH domain

DEPaa 393–462UCSCDomain found in Dishevelled, Egl-10, and Pleckstrin (DEP)

DEPaa 494–563UCSCDomain found in Dishevelled, Egl-10, and Pleckstrin (DEP)

PDZaa 677–746UCSCPDZ domain

Gene Aliases

HGNC Name

phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2

HGNC Previous Symbol

DEPDC2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_024870.4

p.C833F

c.2498G>T

Surrounding Variants

1 paper

NM_024870.4

p.E837K

c.2509G>A

1 paper

NM_024870.4

p.D826A

c.2477A>C

1 paper

NM_024870.4

p.D826G

c.2477A>G

2 papers

NM_024870.4

p.D826N

c.2476G>A

1 paper

NM_024870.4

p.P842A

c.2524C>G

11 papers

NM_024870.4

p.E824*

c.2470G>T

1 paper

NM_024870.4

p.Y823C

c.2468A>G

7 papers

NM_024870.4

p.G844D

c.2531G>A

1 paper

NM_024870.4

p.G820A

c.2459G>C

1 paper

NM_024870.4

p.A850V

c.2549C>T

1 paper

NM_024870.4

p.L810P

c.2429T>C

1 paper

NM_024870.4

p.E806K

c.2416G>A