Varaico: Literature-Extracted Genetic Variants

PRKCA

332 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 339–597UCSCProtein kinase domain

Pkinase_Caa 623–658UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C alpha

HGNC Previous Symbol

PKCA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002737.3

p.R496W

c.1486A>T

Surrounding Variants

1 paper

NM_002737.3

p.T497A

c.1489A>G

1 paper

NM_002737.3

p.P502R

c.1505C>G

9 papers

NM_002737.3

p.M489V

c.1465A>G

1 paper

NM_002737.3

p.E487K

c.1459G>A

1 paper

NM_002737.3

p.K486N

c.1458G>C

1 paper

NM_002737.3

p.K486N

c.1458G>T

2 papers

NM_002737.3

p.A506T

c.1516G>A

2 papers

NM_002737.3

p.A506V

c.1517C>T

1 paper

NM_002737.3

p.P507L

c.1520C>T

5 papers

NM_002737.3

p.D481E

c.1443C>A

5 papers

NM_002737.3

p.D481E

c.1443C>G

1 paper

NM_002737.3

p.D481A

c.1442A>C