Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

1–12 of 271 variants

13 papers

NM_002738.7

p.D427N

c.1279G>A

8 papers

NM_002738.7

p.S352G

c.1054A>G

7 papers

NM_002738.7

p.S660A

c.1978T>G

6 papers

NM_002738.7

p.R22H

c.65G>A

6 papers

NM_002738.7

p.D630N

c.1888G>A

5 papers

NM_002738.7

p.N182K

c.546C>G

5 papers

NM_002738.7

p.K371R

c.1112A>G

5 papers

NM_002738.7

p.T641A

c.1921A>G

4 papers

NM_002738.7

p.D235N

c.703G>A

4 papers

NM_002738.7

p.E655K

c.1963G>A

3 papers

NM_002738.7

p.K29N

c.87G>C

3 papers

NM_002738.7

p.G92V

c.275G>T