Varaico: Literature-Extracted Genetic Variants

RPA1

391 papers

RefSeq Summary

This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important rol...

Pfam Domains

Rep-A_Naa 5–104UCSCReplication factor-A protein 1, N-terminal domain

tRNA_anti-codonaa 197–285UCSCOB-fold nucleic acid binding domain

REPA_OB_2aa 305–402UCSCReplication protein A OB domain

Rep_fac-A_Caa 461–606UCSCReplication factor-A C terminal domain

Gene Aliases

HGNC Name

replication protein A1

HGNC Alias Symbols

REPA1; RPA70; HSSB; RF-A; RP-A

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002945.5

p.S38I

c.113G>T

Surrounding Variants

2 papers

NM_002945.5

p.S38N

c.113G>A

2 papers

NM_002945.5

p.P39T

c.115C>A

1 paper

NM_002945.5

p.P39L

c.116C>T

1 paper

NM_002945.5

p.P39P

c.117G>A

1 paper

NM_002945.5

p.P40L

c.119C>T

1 paper

NM_002945.5

p.G36E

c.107G>A

1 paper

NM_002945.5

p.R41C

c.121C>T

1 paper

NM_002945.5

p.Y42N

c.124T>A

1 paper

NM_002945.5

p.Y42C

c.125A>G

7 papers

NM_002945.5

p.Y42F

c.125A>T

5 papers

NM_002945.5

p.I33S

c.98T>G

1 paper

NM_002945.5

p.P32L

c.95C>T