Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_139276.3

p.L706M

c.2116C>A

Surrounding Variants

1 paper

NM_139276.3

p.L706R

c.2117T>G

1 paper

NM_139276.3

p.L706P

c.2117T>C

1 paper

NM_139276.3

p.L706Q

c.2117T>A

1 paper

NM_139276.3

p.Y705Y

c.2115C>T

1 paper

NM_139276.3

p.Y705*

c.2115C>G

1 paper

NM_139276.3

p.Y705*

c.2115C>A

141 papers

NM_139276.3

p.Y705F

c.2114A>T

6 papers

NM_139276.3

p.Y705C

c.2114A>G

2 papers

NM_139276.3

p.Y705S

c.2114A>C

1 paper

NM_139276.3

p.Y705D

c.2113T>G

4 papers

NM_139276.3

p.Y705H

c.2113T>C

1 paper

NM_139276.3

p.Y705N

c.2113T>A