Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003265.3

p.E778K

c.2332G>A

Surrounding Variants

1 paper

NM_003265.3

p.S775F

c.2324C>T

8 papers

NM_003265.3

p.W769*

c.2307G>A

8 papers

NM_003265.3

p.W769*

c.2306G>A

2 papers

NM_003265.3

p.K767*

c.2299A>T

2 papers

NM_003265.3

p.R791G

c.2371A>G

1 paper

NM_003265.3

p.Y764F

c.2291A>T

7 papers

NM_003265.3

p.A795P

c.2383G>C

3 papers

NM_003265.3

p.A795S

c.2383G>T

4 papers

NM_003265.3

p.A795V

c.2384C>T

3 papers

NM_003265.3

p.Y759F

c.2276A>T

1 paper

NM_003265.3

p.Y759H

c.2275T>C

1 paper

NM_003265.3

p.E799E

c.2397A>G