Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.A189delFs

c.565_566delGC

Surrounding Variants

2 papers

NM_000546.6

p.A189A

c.567C>T

5 papers

NM_000546.6

p.A189fs

c.565_566fs

16 papers

NM_000546.6

p.P190fs

c.568_569fs

70 papers

NM_000546.6

p.A189V

c.566C>T

40 papers

NM_000546.6

p.P190S

c.568C>T

NM_001126118.2

p.P151S

c.451C>T

13 papers

NM_000546.6

p.A189G

c.566C>G

3 papers

NM_000546.6

p.P190A

c.568C>G

1 paper

NM_000546.6

p.A189insFs

c.566_567ins4

1 paper

NM_000546.6

p.A189insFs

c.566_567insA

43 papers

NM_000546.6

p.P190T

c.568C>A

13 papers

NM_000546.6

p.A189D

c.566C>A

7 papers

NM_000546.6

p.A189delFs

c.565delC