Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

15 papers

NM_000546.6

p.L26delFs

c.78delA

Surrounding Variants

27 papers

NM_000546.6

p.P27fs

c.79_80fs

53 papers

NM_000546.6

p.P27S

c.79C>T

20 papers

NM_000546.6

p.P27A

c.79C>G

2 papers

NM_000546.6

p.L26_P27insFs

c.78_79insT

19 papers

NM_000546.6

p.P27T

c.79C>A

1 paper

NM_000546.6

p.L26insFs

c.77_78ins4

6 papers

NM_000546.6

p.L26fs

c.76_77fs

1 paper

NM_000546.6

p.L26L

c.78T>G

2 papers

NM_000546.6

p.L26L

c.78T>C

2 papers

NM_000546.6

p.L26L

c.78T>A

36 papers

NM_000546.6

p.P27L

c.80C>T

12 papers

NM_000546.6

p.P27R

c.80C>G