Varaico: Literature-Extracted Genetic Variants

WNK4

289 papers

RefSeq Summary

This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption ...

Pfam Domains

Pkinaseaa 174–432UCSCProtein kinase domain

OSR1_Caa 453–515UCSCOxidative-stress-responsive kinase 1 C-terminal domain

CCTL2_WNKaa 673–750UCSCWNK CCTL2 domain

Gene Aliases

HGNC Name

WNK lysine deficient protein kinase 4

HGNC Previous Symbol

PRKWNK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

13 papers

NM_032387.5

p.E559K

c.1675G>A

Surrounding Variants

1 paper

NM_032387.5

p.P558H

c.1673C>A

2 papers

NM_032387.5

p.E560G

c.1679A>G

1 paper

NM_032387.5

p.P561Q

c.1682C>A

5 papers

NM_032387.5

p.P561L

c.1682C>T

7 papers

NM_032387.5

p.P556T

c.1666C>A

38 papers

NM_032387.5

p.E562K

c.1684G>A

2 papers

NM_032387.5

p.E562G

c.1685A>G

1 paper

NM_032387.5

p.E562V

c.1685A>T

3 papers

NM_032387.5

p.P555R

c.1664C>G

1 paper

NM_032387.5

p.E562D

c.1686G>C

1 paper

NM_032387.5

p.P555A

c.1663C>G

3 papers

NM_032387.5

p.D564N

c.1690G>A