Varaico: Literature-Extracted Genetic Variants

PRKCA

332 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 339–597UCSCProtein kinase domain

Pkinase_Caa 623–658UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C alpha

HGNC Previous Symbol

PKCA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

18 papers

NM_002737.3

p.D463H

c.1387G>C

Surrounding Variants

5 papers

NM_002737.3

p.D463N

c.1387G>A

4 papers

NM_002737.3

p.D463A

c.1388A>C

1 paper

NM_002737.3

p.D467N

c.1399G>A

1 paper

NM_002737.3

p.N468S

c.1403A>G

1 paper

NM_002737.3

p.N468I

c.1403A>T

2 papers

NM_002737.3

p.V469I

c.1405G>A

1 paper

NM_002737.3

p.M470I

c.1410G>A

1 paper

NM_002737.3

p.M470I

c.1410G>C

1 paper

NM_002737.3

p.M470I

c.1410G>T

1 paper

NM_002737.3

p.D472N

c.1414G>A

1 paper

NM_002737.3

p.S473A

c.1417T>G

1 paper

NM_002737.3

p.H476R

c.1427A>G