Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

1–12 of 885 variants

228 papers

NM_002880.4

p.S257L

c.770C>T

92 papers

NM_002880.4

p.L613V

c.1837C>G

59 papers

NM_002880.4

p.S259A

c.775T>G

53 papers

NM_002880.4

p.P261S

c.781C>T

44 papers

NM_002880.4

p.S259F

c.776C>T

35 papers

NM_002880.4

p.Y341D

c.1021T>G

34 papers

NM_002880.4

p.Y340D

c.1018T>G

30 papers

NM_002880.4

p.K375M

c.1124A>T

28 papers

NM_002880.4

p.S621A

c.1861T>G

27 papers

NM_002880.4

p.P261L

c.782C>T

25 papers

NM_002880.4

p.S338A

c.1012T>G

25 papers

NM_002880.4

p.E478K

c.1432G>A