Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

1–12 of 365 variants

206 papers

NM_003265.3

p.L412F

c.1234C>T

54 papers

NM_003265.3

p.P554S

c.1660C>T

48 papers

NM_003265.3

p.F459F

c.1377C>T

20 papers

NM_003265.3

p.N284I

c.851A>T

18 papers

NM_003265.3

p.L297V

c.889C>G

14 papers

NM_003265.3

p.E746*

c.2236G>T

12 papers

NM_003265.3

p.F303S

c.908T>C

12 papers

NM_003265.3

p.G743D

c.2228G>A

12 papers

NM_003265.3

p.R867Q

c.2600G>A

11 papers

NM_003265.3

p.L360P

c.1079T>C

10 papers

NM_003265.3

p.Q3K

c.7C>A

10 papers

NM_003265.3

p.Y307D

c.919T>G