Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

1–12 of 812 variants

1464 papers

NM_138554.5

p.D299G

c.896A>G

1035 papers

NM_138554.5

p.T399I

c.1196C>T

39 papers

NM_138554.5

p.P53P

c.159C>T

25 papers

NM_138554.5

p.R355G

c.1063A>G

18 papers

NM_138554.5

p.P714H

c.2141C>A

12 papers

NM_138554.5

p.N329S

c.986A>G

11 papers

NM_138554.5

p.N361S

c.1082A>G

10 papers

NM_138554.5

p.C281Y

c.842G>A

10 papers

NM_138554.5

p.Y292N

c.874T>A

10 papers

NM_138554.5

p.I450I

c.1350T>C

9 papers

NM_138554.5

p.H199H

c.597T>C

9 papers

NM_138554.5

p.Q510H

c.1530G>T