Varaico: Literature-Extracted Genetic Variants

LCK

326 papers

RefSeq Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-termina...

Pfam Domains

SH3_1aa 67–113UCSCSH3 domain

SH2aa 127–209UCSCSH2 domain

PK_Tyr_Ser-Thraa 245–494UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LCK proto-oncogene, Src family tyrosine kinase

HGNC Previous Name

lymphocyte-specific protein tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

1–12 of 255 variants

16 papers

NM_005356.5

p.Y505F

c.1514A>T

13 papers

NM_005356.5

p.L341P

c.1022T>C

6 papers

NM_005356.5

p.G201S

c.601G>A

5 papers

NM_005356.5

p.D63Splc

c.188-2A>G

5 papers

NM_005356.5

p.Y394F

c.1181A>T

4 papers

NM_005356.5

p.P26R

c.77C>G

4 papers

NM_005356.5

p.P447L

c.1340C>T

3 papers

NM_005356.5

p.V28L

c.82G>C

3 papers

NM_005356.5

p.K273R

c.818A>G

3 papers

NM_005356.5

p.A353V

c.1058C>T

3 papers

NM_005356.5

p.S377insFs

c.1129dupA

3 papers

NM_005356.5

p.P440S

c.1318C>T