Varaico: Literature-Extracted Genetic Variants

Gene:PAK1

PAK1

276 papers

RefSeq Summary

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nucle...

Pfam Domains

PBDaa 1–34UCSCP21-Rho-binding domain
PBDaa 74–132UCSCP21-Rho-binding domain
Pkinaseaa 270–521UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 1

HGNC Previous Names

p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21 protein (Cdc42/Rac)-activated kinase 1

Papers
RefSeq ID
Protein change
DNA change
1–12 of 165 variants
36 papers
NM_002576.5
p.K299R
c.896A>G
12 papers
NM_002576.5
p.H83L
c.248A>T
10 papers
NM_002576.5
p.H86L
c.257A>T
10 papers
NM_002576.5
p.L107F
c.319C>T
8 papers
NM_002576.5
p.Y131C
c.392A>G
7 papers
NM_002576.5
p.Y429C
c.1286A>G
6 papers
NM_002576.5
p.S110T
c.328T>A
5 papers
NM_002576.5
p.P121L
c.362C>T
5 papers
NM_002576.5
p.S133P
c.397T>C
5 papers
NM_002576.5
p.D183del1
c.547_548delATC
4 papers
NM_002576.5
p.S382L
c.1145C>T
4 papers
NM_002576.5
p.D389N
c.1165G>A
UCSC Genome Browser·Imprint·Privacy·Terms·Feedback·Email Updates·

Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."