Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

1–12 of 539 variants

26 papers

NM_005030.6

p.K82M

c.245A>T

20 papers

NM_005030.6

p.K82R

c.245A>G

14 papers

NM_005030.6

p.T210A

c.628A>G

10 papers

NM_005030.6

p.K540M

c.1619A>T

7 papers

NM_005030.6

p.S137A

c.409T>G

6 papers

NM_005030.6

p.K492R

c.1475A>G

5 papers

NM_005030.6

p.D194A

c.581A>C

4 papers

NM_005030.6

p.V415A

c.1244T>C

4 papers

NM_005030.6

p.S595L

c.1784C>T

3 papers

NM_005030.6

p.R136G

c.406A>G

3 papers

NM_005030.6

p.Q165*

c.493C>T

3 papers

NM_005030.6

p.D176N

c.526G>A