Varaico: Literature-Extracted Genetic Variants

RPA1

391 papers

RefSeq Summary

This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important rol...

Pfam Domains

Rep-A_Naa 5–104UCSCReplication factor-A protein 1, N-terminal domain

tRNA_anti-codonaa 197–285UCSCOB-fold nucleic acid binding domain

REPA_OB_2aa 305–402UCSCReplication protein A OB domain

Rep_fac-A_Caa 461–606UCSCReplication factor-A C terminal domain

Gene Aliases

HGNC Name

replication protein A1

HGNC Alias Symbols

REPA1; RPA70; HSSB; RF-A; RP-A

Papers

RefSeq ID

Protein change

DNA change

1–12 of 376 variants

12 papers

NM_002945.5

p.D228Y

c.682G>T

8 papers

NM_002945.5

p.E240K

c.718G>A

7 papers

NM_002945.5

p.Y42F

c.125A>T

5 papers

NM_002945.5

p.I33S

c.98T>G

5 papers

NM_002945.5

p.L221P

c.662T>C

5 papers

NM_002945.5

p.E277A

c.830A>C

5 papers

NM_002945.5

p.T351A

c.1051A>G

5 papers

NM_002945.5

p.R389W

c.1165C>T

5 papers

NM_002945.5

p.G434R

c.1300G>A

5 papers

NM_002945.5

p.G434R

c.1300G>C

4 papers

NM_002945.5

p.Q4Q

c.12A>G

4 papers

NM_002945.5

p.R31H

c.92G>A