Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

1–12 of 1366 variants

203 papers

NM_139276.3

p.Y640F

c.1919A>T

141 papers

NM_139276.3

p.Y705F

c.2114A>T

140 papers

NM_139276.3

p.D661Y

c.1981G>T

132 papers

NM_139276.3

p.R382W

c.1144C>T

95 papers

NM_139276.3

p.V637M

c.1909G>A

91 papers

NM_139276.3

p.R382Q

c.1145G>A

80 papers

NM_139276.3

p.S614R

c.1840A>C

80 papers

NM_139276.3

p.S614R

c.1842C>G

80 papers

NM_139276.3

p.S614R

c.1842C>A

77 papers

NM_139276.3

p.S727A

c.2179T>G

74 papers

NM_139276.3

p.N647I

c.1940A>T

70 papers

NM_139276.3

p.D661V

c.1982A>T