Varaico: Literature-Extracted Genetic Variants

SYK

362 papers

RefSeq Summary

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to down...

Pfam Domains

SH2aa 15–92UCSCSH2 domain

SH2aa 168–244UCSCSH2 domain

PK_Tyr_Ser-Thraa 371–626UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

spleen associated tyrosine kinase

HGNC Previous Name

spleen tyrosine kinase

Papers

RefSeq ID

Protein change

DNA change

1–12 of 390 variants

8 papers

NM_003177.7

p.S550Y

c.1649C>A

7 papers

NM_003177.7

p.Y246C

c.737A>G

7 papers

NM_003177.7

p.K402R

c.1205A>G

6 papers

NM_003177.7

p.T371M

c.1112C>T

6 papers

NM_003177.7

p.S550F

c.1649C>T

5 papers

NM_003177.7

p.A353T

c.1057G>A

5 papers

NM_003177.7

p.M450I

c.1350G>A

4 papers

NM_003177.7

p.E130G

c.389A>G

4 papers

NM_003177.7

p.P301L

c.902C>T

4 papers

NM_003177.7

p.Y348F

c.1043A>T

4 papers

NM_003177.7

p.Y352F

c.1055A>T

4 papers

NM_003177.7

p.K387R

c.1160A>G