Varaico: Literature-Extracted Genetic Variants

PRKCA

332 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 339–597UCSCProtein kinase domain

Pkinase_Caa 623–658UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C alpha

HGNC Previous Symbol

PKCA

Papers

RefSeq ID

Protein change

DNA change

1–12 of 282 variants

18 papers

NM_002737.3

p.D463H

c.1387G>C

11 papers

NM_002737.3

p.D294G

c.881A>G

9 papers

NM_002737.3

p.M489V

c.1465A>G

7 papers

NM_002737.3

p.A25E

c.74C>A

6 papers

NM_002737.3

p.K368R

c.1103A>G

5 papers

NM_002737.3

p.D463N

c.1387G>A

5 papers

NM_002737.3

p.D481E

c.1443C>A

5 papers

NM_002737.3

p.D481E

c.1443C>G

4 papers

NM_002737.3

p.D463A

c.1388A>C

3 papers

NM_002737.3

p.R238Q

c.713G>A

3 papers

NM_002737.3

p.A444V

c.1331C>T

3 papers

NM_002737.3

p.P514L

c.1541C>T